Publications

2007

Human Cep192 is required for mitotic centrosome and spindle assembly.

Gomez-Ferreria MA, Rath U, Buster DW, Chanda SK, Caldwell JS, Rines DR, Sharp DJ.

Curr Biol. 2007 Nov 20;17(22):1960-6. doi: 10.1016/j.cub.2007.10.019. Epub 2007 Nov 1.

PMID: 17980596

A role for IkappaB kinase 2 in bipolar spindle assembly.

Irelan JT, Murphy TJ, DeJesus PD, Teo H, Xu D, Gomez-Ferreria MA, Zhou Y, Miraglia LJ, Rines DR, Verma IM, Sharp DJ, Tergaonkar V, Chanda SK.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16940-5. doi: 10.1073/pnas.0706493104. Epub 2007 Oct 15.

PMID: 17939994 Free PMC article.

A probability-based approach for the analysis of large-scale RNAi screens.

König R, Chiang CY, Tu BP, Yan SF, DeJesus PD, Romero A, Bergauer T, Orth A, Krueger U, Zhou Y, Chanda SK.

Nat Methods. 2007 Oct;4(10):847-9. doi: 10.1038/nmeth1089. Epub 2007 Sep 9.

PMID: 17828270

B cell terminal differentiation factor XBP-1 induces reactivation of Kaposi's sarcoma-associated herpesvirus.

Yu F, Feng J, Harada JN, Chanda SK, Kenney SC, Sun R.

FEBS Lett. 2007 Jul 24;581(18):3485-8. doi: 10.1016/j.febslet.2007.06.056. Epub 2007 Jun 29.

PMID: 17617410

Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus.

Yu F, Harada JN, Brown HJ, Deng H, Song MJ, Wu TT, Kato-Stankiewicz J, Nelson CG, Vieira J, Tamanoi F, Chanda SK, Sun R.

PLoS Pathog. 2007 Mar;3(3):e44. doi: 10.1371/journal.ppat.0030044.

PMID: 17397260 Free PMC article.

2006

Isolation, characterization, and genetic complementation of a cellular mutant resistant to retroviral infection.

Agarwal S, Harada J, Schreifels J, Lech P, Nikolai B, Yamaguchi T, Chanda SK, Somia NV.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15933-8. doi: 10.1073/pnas.0602674103. Epub 2006 Oct 16.

PMID: 17043244 Free PMC article.

Genome-wide functional analysis of human cell-cycle regulators.

Mukherji M, Bell R, Supekova L, Wang Y, Orth AP, Batalov S, Miraglia L, Huesken D, Lange J, Martin C, Sahasrabudhe S, Reinhardt M, Natt F, Hall J, Mickanin C, Labow M, Chanda SK, Cho CY, Schultz PG.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14819-24. doi: 10.1073/pnas.0604320103. Epub 2006 Sep 25.

PMID: 17001007 Free PMC article.

Minimizing the risk of reporting false positives in large-scale RNAi screens.

Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, Ma Y, Mathey-Prévôt B, Root DE, Sabatini DM, Taipale J, Perrimon N, Bernards R.

Nat Methods. 2006 Oct;3(10):777-9. doi: 10.1038/nmeth1006-777.

PMID: 16990807

Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling.

Cho CY, Koo SH, Wang Y, Callaway S, Hedrick S, Mak PA, Orth AP, Peters EC, Saez E, Montminy M, Schultz PG, Chanda SK.

Cell Metab. 2006 May;3(5):367-78. doi: 10.1016/j.cmet.2006.03.006.

PMID: 16679294

A functional genomics approach to the mode of action of apratoxin A.

Luesch H, Chanda SK, Raya RM, DeJesus PD, Orth AP, Walker JR, Izpisúa Belmonte JC, Schultz PG.

Nat Chem Biol. 2006 Mar;2(3):158-67. doi: 10.1038/nchembio769. Epub 2006 Feb 12.

PMID: 16474387

High-content screening of functional genomic libraries.

Rines DR, Tu B, Miraglia L, Welch GL, Zhang J, Hull MV, Orth AP, Chanda SK.

Methods Enzymol. 2006;414:530-65. doi: 10.1016/S0076-6879(06)14028-8.

PMID: 17110210

2005

Identification of novel mammalian growth regulatory factors by genome-scale quantitative image analysis

Harada JN, Bower KE, Orth AP, Callaway S, Nelson CG, Laris C, Hogenesch JB, Vogt PK, Chanda SK.

Genome Res. 2005 Aug;15(8):1136-44. doi: 10.1101/gr.3889305. Epub 2005 Jul 15.

PMID: 16024821 Free PMC article.

Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.

Liu J, Bang AG, Kintner C, Orth AP, Chanda SK, Ding S, Schultz PG.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1927-32. doi: 10.1073/pnas.0409472102. Epub 2005 Jan 26.

PMID: 15677333 Free PMC article.

Methods for the functional genomic analysis of ubiquitin ligases.

Li W, Chanda SK, Micik I, Joazeiro CA.

Methods Enzymol. 2005;398:280-91. doi: 10.1016/S0076-6879(05)98023-3.

PMID: 16275336

2004

The promise of genomics to identify novel therapeutic targets.

Orth AP, Batalov S, Perrone M, Chanda SK.

Expert Opin Ther Targets. 2004 Dec;8(6):587-96. doi: 10.1517/14728222.8.6.587.

PMID: 15584864 Review.

PDX1, a cellular homeoprotein, binds to and regulates the activity of human cytomegalovirus immediate early promoter.

Chao SH, Harada JN, Hyndman F, Gao X, Nelson CG, Chanda SK, Caldwell JS.

J Biol Chem. 2004 Apr 16;279(16):16111-20. doi: 10.1074/jbc.M312304200. Epub 2004 Feb 5.

PMID: 14764605

Identification of p53 regulators by genome-wide functional analysis.

Huang Q, Raya A, DeJesus P, Chao SH, Quon KC, Caldwell JS, Chanda SK, Izpisua-Belmonte JC, Schultz PG.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3456-61. doi: 10.1073/pnas.0308562100. Epub 2004 Feb 27.

PMID: 14990790 Free PMC article.

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.

Zeisig BB, Milne T, García-Cuéllar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK.

Mol Cell Biol. 2004 Jan;24(2):617-28. doi: 10.1128/MCB.24.2.617-628.2004.

PMID: 14701735 Free PMC article.

2020

Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.

Yuin Ho JS, Wing-Yee Mok B, Campisi L, Jordan T, Yildiz S, Parameswaran S, Wayman JA, Gaudreault NN, Meekins DA, Indran SV, Morozov I, Trujillo JD, Fstkchyan YS, Rathnasinghe R, Zhu Z, Zheng S, Zhao N, White K, Ray-Jones H, Malysheva V, Thiecke MJ, Lau SY, Liu H, Junxia Zhang A, Chak-Yiu Lee A, Liu WC, Aydillo T, Salom Melo B, Guccione E, Sebra R, Shum E, Bakker J, Kaufman DA, Moreira AL, Carossino M, Balasuriya UBR, Byun M, Miraldi ER, Albrecht RA, Schotsaert M, Garcia-Sastre A, Chanda SK, Jeyasekharan AD, TenOever BR, Spivakov M, Weirauch MT, Heinz S, Chen H, Benner C, Richt JA, Marazzi I.

bioRxiv. 2020 Dec 1:2020.12.01.404483. doi: 10.1101/2020.12.01.404483. Preprint.

PMID: 33299999 Free PMC article. Updated.

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.

Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD.
Cell. 2020 Nov 12;183(4):1043-1057.e15. doi: 10.1016/j.cell.2020.09.033. Epub 2020 Sep 14.
PMID: 32970989 Free PMC article

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.

Miorin L, Kehrer T, Sanchez-Aparicio MT, Zhang K, Cohen P, Patel RS, Cupic A, Makio T, Mei M, Moreno E, Danziger O, White KM, Rathnasinghe R, Uccellini M, Gao S, Aydillo T, Mena I, Yin X, Martin-Sancho L, Krogan NJ, Chanda SK, Schotsaert M, Wozniak RW, Ren Y, Rosenberg BR, Fontoura BMA, García-Sastre A.

Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28344-28354. doi: 10.1073/pnas.2016650117. Epub 2020 Oct 23.

PMID: 33097660 Free PMC article.

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.

Riva L, Yuan S, Yin X, Martin-Sancho L, Matsunaga N, Pache L, Burgstaller-Muehlbacher S, De Jesus PD, Teriete P, Hull MV, Chang MW, Chan JF, Cao J, Poon VK, Herbert KM, Cheng K, Nguyen TH, Rubanov A, Pu Y, Nguyen C, Choi A, Rathnasinghe R, Schotsaert M, Miorin L, Dejosez M, Zwaka TP, Sit KY, Martinez-Sobrido L, Liu WC, White KM, Chapman ME, Lendy EK, Glynne RJ, Albrecht R, Ruppin E, Mesecar AD, Johnson JR, Benner C, Sun R, Schultz PG, Su AI, García-Sastre A, Chatterjee AK, Yuen KY, Chanda SK.

Nature. 2020 Oct;586(7827):113-119. doi: 10.1038/s41586-020-2577-1. Epub 2020 Jul 24.

PMID: 32707573 Free PMC article.

Functional Landscape of SARS-CoV-2 Cellular Restriction.

Martin-Sancho L, Lewinski MK, Pache L, Stoneham CA, Yin X, Pratt D, Churas C, Rosenthal SB, Liu S, De Jesus PD, O'Neill AM, Gounder AP, Nguyen C, Pu Y, Oom AL, Miorin L, Rodriguez-Frandsen A, Urbanowski M, Shaw ML, Chang MW, Benner C, Frieman MB, García-Sastre A, Ideker T, Hultquist JF, Guatelli J, Chanda SK.

bioRxiv. 2020 Sep 30:2020.09.29.319566. doi: 10.1101/2020.09.29.319566. Preprint.

PMID: 33024967 Free PMC article. Updated.

The E3 Ubiquitin-Protein Ligase Cullin 3 Regulates HIV-1 Transcription.

Langer S, Yin X, Diaz A, Portillo AJ, Gordon DE, Rogers UH, Marlett JM, Krogan NJ, Young JAT, Pache L, Chanda SK.

Cells. 2020 Sep 1;9(9):2010. doi: 10.3390/cells9092010.

PMID: 32882949 Free PMC article.

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.

Clausen TM, Sandoval DR, Spliid CB, Pihl J, Painter CD, Thacker BE, Glass CA, Narayanan A, Majowicz SA, Zhang Y, Torres JL, Golden GJ, Porell R, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser B, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Leibel SL, Chanda SK, Schmidt AG, Godula K, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD.

bioRxiv. 2020 Jul 14:2020.07.14.201616. doi: 10.1101/2020.07.14.201616. Preprint.

PMID: 32699853 Free PMC article. Updated.

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals.

Riva L, Yuan S, Yin X, Martin-Sancho L, Matsunaga N, Burgstaller-Muehlbacher S, Pache L, De Jesus PP, Hull MV, Chang M, Chan JF, Cao J, Poon VK, Herbert K, Nguyen TT, Pu Y, Nguyen C, Rubanov A, Martinez-Sobrido L, Liu WC, Miorin L, White KM, Johnson JR, Benner C, Sun R, Schultz PG, Su A, Garcia-Sastre A, Chatterjee AK, Yuen KY, Chanda SK.

bioRxiv. 2020 Apr 17:2020.04.16.044016. doi: 10.1101/2020.04.16.044016. Preprint.

PMID: 32511357 Free PMC article.

Sensor Sensibility-HIV-1 and the Innate Immune Response.

Yin X, Langer S, Zhang Z, Herbert KM, Yoh S, König R, Chanda SK.

Cells. 2020 Jan 20;9(1):254. doi: 10.3390/cells9010254.

PMID: 31968566 Free PMC article. Review.